I myself play a lot of WoD, I used to play DnD, up until around the cusp of 2nd and 3rd editions. I never played 3.5 per-se, and was contemplating trying pathfinder when DnD 4.0 came out (it didn't do anything for me at all). Hearing about 5.0 seems like it is just more of WOTC trying to make a "lets everyone hold hands and play nice with the system" when they already have lost many a person to pathfinder.
I came to discover that "class limitation" systems, levels and "exp required to get to character level X" make gaming sometimes, in some cases feel like a video game. While I truly do miss the "fantasy" setting provided by some of the DnD supplements and worlds, I have come to discover that WoD more or less has been trying to "clean up" their systems since the VTM 20A launch.
While I am particularly impressed with the "no character level" system that WoD puts out, it still goes to reason that there can be a difference in power between characters, without breaking (or monetizing) the system. Though characters have no "class skills" they do have things such as "clan disciplines" or "house lores" etc etc (whatever book your playing). These various flavors while still allowing a character to improve themselves, don't necessarily restrict general growth; using VTM as an example, If a person really wanted to play a rouge-like type of character, they could just as well be a malkavian, nosferatu or ravnos, but all the same, if they didn't want to play a character who uses sneaky obfuscate (A cloaking power which makes you less noticable), it doesn't restrict them from just as well, dedicating some time to larceny/security, stealth or dexterity, all of which are vital for the typical "sneaking around corners" types.
These type of "molds" help build "character concepts" without having a class tell you down to the letter what you can and cant do. My biggest concern is the 14 year old kid who wants to play a 200 year old elder, but has the life experience and player mentality (ergo his character reflects this in their behaviorism) of a 14 year old, then again, I suppose any DM would have the same type of munchkin issue for people who make ridiculous cross classing in DnD games (Paladin/Rogue anyone?).
I find that WoD games are a bit more "demanding" of their players seriousness (or at least in practicality), as opposed to the good times some people might have just spent in their basement playing DnD for hours on end. Such is the tradeoff of playing a game that doesn't give you guideline character creation safety nets. Find the right group however, and its good times for everyone..