Since I can't get 3 to work on my craptop, I've only ever played a little bit of New Vegas. I'm not too fond of it, tbh, so I don't have high hopes for 4.
I'm excited for it when/if it ever comes out haha.
I really hope they update the character customization though, New Vegas didn't seem any better than 3 in that area. mad
Supposedly the next Fallout is taking place in Boston. That means we might finally get to see more of the Commonwealth that is mentioned here and there in Fallout 3.