No real reward.
The items that can only be made by alchemists are awesome, and are worth more. The problem is stupid impatient sellers that would rather lose millions of gold than wait a few weeks for a seller. Because the market for alchemy items is slow, they pretty much kill any chance of profit for the people who ARE patient enough to wait for the right buyer to come along.
I feel silly now. I *just* found out that I did NOT loss all those expensive items that i bought in order to make my alchemy project. I didn't even have to re-buy the formula! All I had to do was pay 2k in order to redo the "creation" process. =D