The new Assassins Creed of course!!
Aaaaand.... hrm..... I really wanna see what Nintendo is bringing to the table this year. They better be showing some Monster Hunter climbing walls, controlling bugs and.... turning axes into sword and shield??
Zelda Wii U, Majora's Mask (Wii U?) , F-Zero, and I KNOW THIS IS WAY OUT but maybe another Remake of mario 64 for either 3ds or wii U. ( I only care about first party Nintendo games for Nintendo systems)
*Edit: some videos on Pokemon R/S would be good as well