Suggestions:
Active-
Amya Chronicles-High fantasy epic, gorgeous art, and an large cast a plot. And if you're into supporting webcomics, it has 4 days left on it's kickstarter
Guilded Age-Another high fantasy comic, an MMORPG, genre parodying, punfest.
Supernormal Step-In a world where there is not city named boston, there is also no band named Boston. The MC thinks this is a great crime. That, and absolute power corrupts absolutely.
DMFA-It's got anthropomorphic animals as the main cast, but it's still awesome, and does a great mix of laughing your a** off, world building, and making you cry uncontrollably
El Goonish Shive-A story of higschoolers dealing with life, love, lasers, labs, transgender birthday parties, magical hammers and fairies, and a lovable squirrel girl.
Inactive/Finished/Slow Updater-
Captain SNES-A sprite comic. 13 years in the making, a huge plot, massive cast, and so much nostalgia, nuance, and dark comedy, it's almost hard to wait one to two months for an update....
Goblins-A DnD based webcomic, it has wonderful art, an interesting perspective, and for action fans, a decent amount of blood and gore. Currently on hiatus.
Dominid Deegan-Oracle for Hire:The pun master. Amazing characters, puns that while painful, you still go back to, and a fun, interesting world. Completed. At exactly 3000 pages
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