I happen to have enjoyed it, though admittedly, not until the second issue.
Deadpool takes his bending of the fourth wall to Eleven, and starts to kill other Super Heroes through shear force of "Deadpool Kills the Marvel Universe" being printed on the cover of the comic.
Also, I thought the bit where he killed the Watcher was hilarious.
Edit: Also, the fourth issue features Deadpool taking out the Punisher right on the cover. It's well aware Punisher did it first, and probably wouldn't exist if Punisher hadn't done it first.
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