Touchable Intern
watch grave of the fireflies
Yeah, if you wanna have a good cry. "Barefoot Gen", but that has a happy(ish) ending. Ya know, in the same way "Alas, Babylon" has a good ending compared to "The Day After".
Daring and ballsy anime: "Paranoia Agent", "AKIRA" (official title is all caps), "5 Centimeters Per Second" (even if it doesn't seem like it after the first act, keep watching!), "The Astonishing Works of Tezuka Osamu", if you're willing to read with your eyes, then I HIGHLY recommend finding Yoshihiro Tatsumi's "Abandon the Old in Tokyo",
Anime that doesn't immediately seem like anything special BUT TOTALLY IS: "Neon Genesis (********) Evangelion", "Darker than Black" (my favorite of all time), "Baccano!", and probably one of my favorite movies of all time, "The Girl Who Leaped Through Time", and while I personally don't like it, everyone else who has watched it ******** loves it, so I'll slap "Eden of the East" on here.