I hate it when they have ridiculously pointy noses, like in Escaflowne, and I think in Witch Hunter Robin, but not quite as bad. And, like how some other people mentioned, when there are CGed things and anime things on at the same time. And recently I was slightly disturbed by unnecessary boob jiggling, such as was mentioned before, but accompanied with a disturbing sound effect... Not a bouncing one, like you'd think, a sloshing one...