When Banagher Links got Loni to stop killing everything in Unicorn Gundam Ep 4. Only to have Riddhe take the beam magnum and liquify her along with the mobile armor.
I couldn't find a clip of it but the scene in InuYasha when that little girl is being dragged to hell and she thinks her mother is mad at her.
(Ayasa best girl btw but this scene was way sadder and dramatic)
7:18 - 14:49
(sorry about the dub bleh)
main ones I can think of right now , most of those only made me tear up a bit the only ones that actually made me cry hard was Anohana and grave of the fireflies, the other ones made me tear up a bit though.
OMG that InuYasha episode. I believe it was season 1 episode 12, that episode makes me cry so much every single time