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I have added Madoka to my list 3nodding
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Mahou Shoujo Madoka Magika. Although, a manga based off of the anime exists, but, it came after the anime.
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Oh, yeah, there's quite a few, Madoka, Ramen Fighter Miki, .hack// and Tiger and Bunny to name a few.
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Mai HiME was an anime before it became a manga. Noir has no manga to go with it. The Twelve Kingdoms wasn't based on a manga, but a novel series. Star Ocean EX was based on a video game. Witchblade was based around an American comic series. While most animes are based off manga, there are a good deal of anime that are inspired from other areas.
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All the ones I was going to name were already posted. XD

While the .hack anime are based on games, their plots aren't based on the game plots. They're either prequels, sequels, or interquels.

Princess Tutu definitely counts.
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Innocent Venus? :3

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